After treatment discontinuation, PONVORY™ remains in the blood for up to 7 days1*

The elimination of PONVORY™ 
can offer your patients  the 
flexibility they may need, including 
family planning1

Reversible in about 7 days

Remains in
the blood
for up to
7 days1

  • The elimination half-life after oral administration of PONVORY™ is approximately 33 hours1
  • Before initiation of PONVORY™ treatment, women of childbearing potential should be counseled on the potential for a serious risk to the fetus and the need for effective contraception during treatment with PONVORY™1
  • Since it takes approximately 1 week to eliminate PONVORY™ from the body after stopping treatment, the potential risk to the fetus may persist, and women should use effective contraception during this period1
  • There are no adequate and well-controlled studies of PONVORY™ in pregnant women1

*Severe exacerbation of disease, including disease rebound, has been rarely reported after discontinuation of an S1P receptor modulator. Patients should be observed for a severe increase in disability upon discontinuation of PONVORY™ and appropriate treatment should be instituted, as required.1

S1P = sphingosine-1-phosphate.