a highly selective S1P1 receptor modulator1-3
The exact mechanism by which PONVORY™ exerts therapeutic effects is unknown but may involve the reduction of lymphocyte migration into the CNS.1
PONVORY™ binds with high affinity to S1P1 receptors.1
Lymphocytes can invade the CNS as part of an inappropriate immune response, causing inflammation and damage in MS.4,5
PONVORY™ blocks the capacity of lymphocytes to egress from lymph nodes,
reducing the number of lymphocytes in peripheral blood.1
Animal studies show that PONVORY™ readily crosses the blood-brain barrier.1
There are multiple types of cells in the CNS that can express S1P1.
These include microglia, astrocytes, oligodendrocytes, and neurons.6
CNS = central nervous system; MS = multiple sclerosis; S1P1 = sphingosine-1-phosphate 1.