PONVORY™:
 a highly selective S1P1 receptor modulator1-3

The exact mechanism by which PONVORY™ exerts therapeutic effects is unknown but may involve the reduction of lymphocyte migration into the CNS.1

PONVORY™ binds with high affinity to S1P1 receptors1

PONVORY™ binds with high affinity to S1P1 receptors.1

Lymphocytes can invade the CNS as part of an inappropriate immune response, causing inflammation and damage.5,6

Lymphocytes can invade the CNS as part of an inappropriate immune response, causing inflammation and damage in MS.4,5

PONVORY™ blocks the capacity of lymphocytes to egress from lymph nodes, 
reducing the number of lymphocytes in peripheral blood.1

Animal studies show that PONVORY™ readily crosses the blood-brain barrier.1

Animal studies show that PONVORY™ readily crosses the blood-brain barrier.1

There are multiple types of cells in the CNS that can express S1P1.
These include microglia, astrocytes, oligodendrocytes, and neurons.6

CNS = central nervous system; MS = multiple sclerosis; S1P1 = sphingosine-1-phosphate 1.